Catalog Number - 68508-10P

Cogent RP C8™ HPLC Columns are designed for reliable reversed-phase chromatography using a traditional octyl (C8) bonded stationary phase. Manufactured with ultra-high purity silica and fully double end capped bonding technology, these columns provide reproducible retention, excellent peak shape, and long operational life. The RP C8™ phase is a USP L7 equivalent chemistry and is commonly used as an alternative for methods developed on similar C8 columns. Compared to C18 phases, RP C8™ offers reduced hydrophobic retention while maintaining excellent selectivity for many neutral and non-polar compounds.

68508-10P is packed with 5 µm RP C8™ particles featuring a 100 Å pore size in a 4.6 mm ID x 100 mm length format. This column length provides greater resolving power than a 50 mm column while maintaining relatively short run times and moderate solvent consumption. The combination of a 100 mm length and 5 µm particle size makes this column well suited for analytical method development, routine testing, and applications requiring improved separation of closely eluting compounds. The RP C8™ stationary phase is particularly useful for hydrophobic compounds, neutral analytes, and long-chain fatty acids where less retention than a comparable C18 column is desired.

The 100 mm length is often selected when a 50 mm column does not provide sufficient resolution but a longer 150 mm column would unnecessarily increase run times. This balance between efficiency and speed makes the column a popular choice for routine analytical laboratories and LC-MS method development applications.

Key Benefits

• RP C8™ stationary phase

• USP L7 equivalent chemistry

• Octyl (C8) bonded phase

• Fully double end capped

• Ultra-high purity silica support

• 100 Å pore size

• Improved resolution compared to 50 mm columns

• Lower retention than C18 phases

• Low backpressure with 5 µm particles

• Excellent balance of speed and efficiency

Typical Applications

• Reversed-phase HPLC

• Method development

• Pharmaceutical analysis

• Long-chain fatty acid analysis

• Hydrophobic compound separations

• Neutral compound analysis

• Environmental testing

• Food and beverage analysis

• Routine quality control

• LC-MS method development

Specifications

• Product Type: HPLC Column

• Stationary Phase: RP C8™

• USP Classification: L7

• Chromatography Mode: Reversed Phase

• Bonded Phase: Octyl (C8)

• Endcapping: Fully Double End Capped

• Particle Size: 5 µm

• Pore Size: 100 Å

• Column Dimensions: 4.6 mm ID x 100 mm

• Recommended Flow Rate: 1.0-2.0 mL/min

• Column Hardware: Stainless Steel

• Brand: Cogent

Important Notes

• Designed for reversed-phase HPLC separations requiring greater resolution than shorter columns

• Provides lower retention than comparable C18 columns

• Suitable for hydrophobic and moderately non-polar compounds

• Excellent choice for long-chain fatty acid separations

• 100 mm length offers improved resolving power while maintaining efficient run times

• 5 µm particles provide low backpressure and broad instrument compatibility

• Compatible with standard HPLC systems operating at conventional analytical flow rates

• Frequently selected for analytical method development and routine quality control

• Manufactured using ultra-high purity silica and fully double end capped bonding technology